FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles
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چکیده
منابع مشابه
FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles
Forkhead box C1 (FOXC1) is an essential member of the forkhead box transcription factors and has been highlighted as an important transcriptional regulator of crucial proteins associated with a wide variety of carcinomas. FOXC1 regulates tumor-associated genes and is regulated by multiple pathways that control its mRNA expression and protein activity. Aberrant FOXC1 expression is involved in di...
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Sirtuin7 (SIRT7) is a NAD(+)-dependent protein deacetylase which belongs to sirtuin family. Although sirtuin proteins have attracted a great deal of attention, little is known about SIRT7. SIRT7 participates in rDNA transcription in the nucleolus. However, recent reports show that SIRT7 has additional novel functions. This review summarizes all findings about SIRT7, and highlights its critical ...
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Hyaluronidases are a family of five human enzymes that have been differentially implicated in the progression of many solid tumor types, both clinically and in functional studies. Advances in the past 5 years have clarified many apparent contradictions: (1) by demonstrating that specific hyaluronidases have alternative substrates to hyaluronan (HA) or do not exhibit any enzymatic activity, (2) ...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Medical Oncology
سال: 2017
ISSN: 1758-8359,1758-8359
DOI: 10.1177/1758834017742576